Disulfiram, an alcohol-aversive or alcohol-sensitizing agent, causes an acutely toxic physical reaction when mixed with alcohol Manufacturer advises patients and their carers should be counselled on the disulfiram-alcohol reaction—reactions may occur following exposure to small amounts of alcohol found in perfume, aerosol sprays, or low alcohol and "non-alcohol" beers and wines; symptoms may be severe and life-threatening and can include nausea, flushing, palpitations, arrhythmias, hypotension, respiratory depression Feb 1, 2024 · Disulfiram (Oral Route) Do not drink any alcohol, even small amounts, while you are taking this medicine and for 14 days after you stop taking it, because the alcohol may make you very sick
This medicine can react with alcohol even 14 days after you take your last dose
Background
Ingestion of 10-30 g may be
A retrospective review of the use of disulfiram among alcoholic patients being treated for active tuberculosis with isoniazid-containing regimens found no
It is a relatively nontoxic substance when administered alone
A single nucleotide polymorphism (SNP; C-1021T) in the dopamine beta-hydroxylase gene is relevant to paranoia associated with disulfiram pharmacotherapy for cocaine addiction ( 15 )
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Disulfiram hepatotoxicity with jaundice is associated with high mortality and appearance of symptoms or signs of liver injury should lead to its immediate
12-, Z91
underdosing
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Along with its needed effects, disulfiram may cause some unwanted effects
It is only suitable for people who have been through detoxification ('detox') and have stopped drinking alcohol
Cancer is a major health issue worldwide and the global burden of cancer is expected to reduce the costs of treatment as well as prolong the survival time
While taking this medication, avoid alcohol in all forms including Usual Adult Dose for Alcohol Dependence
Drug Characteristics and Pharmacokinetics
In human studies, the half-lives of disulfiram and DDTC are estimated at 7 h and 15 h, respectively [36,50]
Indeed, as pointed out by Brewer, “compared with the toxicity of alcohol, the toxicity of disulfiram is trivial”
Common side effects of Disulfiram include: skin rash, acne, mild headache, tiredness, impotence, loss of interest in sex, and ; metallic or garlic-like taste in the mouth; Serious side effects of Disulfiram include: hives, difficulty breathing, swelling of the face, lips, tongue, or throat, flushing (warmth, redness, or tingly feeling), sweating, Mechanism of Action
Do not administer until patient has abstained from alcohol
Average maintenance dosage: 250 mg daily (range: 125–500 mg daily) until patient is fully recovered socially and a basis for permanent self-control is established
Disulfiram overdose
Ingestion of as little as 7 mL of ethanol can cause a severe reaction in patients taking as little as 200 mg of disulfiram per day
Disulfiram ICD-10-CM Drugs Index
In the current study, we summarize the anti-inflammatory mechanisms of disulfiram and its There are 193 drugs known to interact with disulfiram, along with 5 disease interactions, and 2 alcohol/food interactions
DSM‐IV, ICD‐10)
Severe vomiting might occur requiring administration of intravenous fluids